The original methods for targeting the IGF-I receptor in experimental animals were antisense strategies and dominant-negative mutants of the receptor. They are obsolete. Several antibodies to the ...

Although IR-B is a specific receptor for insulin, IR-A also binds IGF-2 and at lower affinity IGF-1, and may induce biologic effects in response to both IGFs. Second, overexpressed IR enhances the ...

Insulin growth factor 2 (IGF-2) overexpression leading to the activation of the IGF-1 receptor (IGF-1R)/mammalian target of rapamycin (mTOR) pathway is well described in ACC.

The percentage of cells positive for IGF-1R ranged from 0 to 90 % ( 5 had 0%, 19 had > 10% and 17 had ≥ 50%), median 70%. Of the 17 patients with 50% or more cells positive for IGF-1R; 8 had extensive ...

Male and female mice in which the receptor for insulin had been deleted displayed normal timing of puberty and fertility, but male and female mice with the receptor for IGF-1 deleted showed ...

A growth hormone called insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer, according to two complementary studies published in Annals of Oncology.

A new Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice ... a protein that mediates the action of insulin, and IGF-1 receptor, ...

Vitamin D and insulin-like growth factor-1 (IGF-1) are involved in a complex interplay that may have implications for growth hormone dosing, researchers found.

Robert Smith, an endocrinologist at Brown, recently discovered a protein called GIGYF2 that interacts with insulin and IGF-1 receptors. To better understand GIGYF2’s function, Smith mapped the ...

The type 1 insulin-like growth factor I (IGF-IR) receptor plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.