However, we have recently proposed a distinct model to explain the association of aging with the development of skin cancer based on the role of the insulin-like growth factor 1 receptor (IGF-1R ...

IGF-1 signaling is required in many stages of hematopoiesis and inappropriate activation of autocrine IGF-1 signaling may facilitate transformation to blast crisis. We observed that in 8 out of 11 ...

They also found that verapamil promotes IGF-1 signaling in pancreatic beta cells. Type 1 diabetes is an autoimmune disease that causes loss of the pancreatic beta cells that produce insulin. To ...

However, very little has been done to prove absolutely that the expression or activation of the IGF-1 signaling pathway at physiologically relevant levels is sufficient to cause a healthy prostate ...

The authors therefore conclude that IGF-1 signaling is necessary for timely triggering of pulsatile GnRH production at puberty and that it helps coordinate puberty with a specific stage of body ...

Ongoing research aims to delineate its full spectrum of activity, optimal strategies, and the breadth of its implications.

a component of the insulin/IGF-1 signaling pathway. The work suggests that reducing insulin/IGF-1 signaling (IIS), for example, by eating drastically fewer calories, could be one way for humans to ...

These peptides, in turn, activate the insulin-like growth factor 1 (IGF-1) signaling pathway in NSCs and triggers their reactivation. Human NSCs are also activated by IGF-1 signaling. Dormant NSCs ...

Previous studies have revealed that the insulin/insulin-like growth factor 1 (IGF) signaling pathway has an important role in energy metabolism. Other molecular pathways associated with energy ...

Aging-US published "Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling" which reported that the broccoli-derived isothiocyanate sulforaphane ...

elegans through insulin/IGF-1 signaling' The authors used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. Sulforaphane increased the lifespan and promoted a ...