Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting ...

Care of patients with systemic immunoglobulin light chain (AL) amyloidosis has undergone transformative changes, leading to marked, steady progress in outcomes for patients over the past four decades.

Serum Free Light Chain: Immunoglobulin light chains that are circulating in serum in a free state are called free light chains. The analysis of the serum level of FLCs became practical as a clinical ...

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death. Clonal plasma cells in the bone marrow secrete ...

Histopathology of intraoral lesions revealed hematic extravasation and λ light chain deposition on the capillary endothelium. A hematologist performed a bone marrow biopsy, which was diagnostic for ...

Light chain multiple myeloma is a subtype of multiple ... The type depends on the immunoglobulin that a myeloma cell produces, also known as antibodies or M-proteins. According to the ...