Nature Immunology - SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway Skip to main content Thank you for visiting nature.com.

Elevated immunoglobulin free light chain (FLC) level and abnormal FLC ratio are commonly seen in multiple myeloma (MM) and have prognostic implications. We hypothesized that presence of ...

Serum Free Light Chain: Immunoglobulin light chains that are circulating in serum in a free state are called free light chains. The analysis of the serum level of FLCs became practical as a clinical ...

There was a strong correlation between the extent of reduction of amyloidogenic free light chains (FLCs) and improvement in survival. This allowed the identification of four levels of response: ...

Diluted human plasma (1:250 dilution) was added to plates coated with LGL1 (500 ng per well), and the levels of kappa and lambda immunoglobulin light chains were determined with the use of human ...

Immunoglobulin light chain amyloidosis (AL amyloidosis) results from the tissue deposition of amyloid fibrils derived from monoclonal immunoglobulin (M-Ig) light chains (LCs) produced by an indolent ...

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis. 2021-07-01. DOI: 10.1056/NEJMdo006080. Save. Permissions. For permission requests, please contact NEJM Reprints at [email ...

For decades, the diagnosis of multiple myeloma required evidence of end-organ damage characterized by myeloma-defining events ...

Immunoglobulin light chain amyloidosis is a rare condition, with an incidence of nearly 10 per million person-years.1 It is characterized by deposition of misfolded monoclonal immunoglobulin light ...

Serum free light chain assay test: Normally, the light chains kappa and lambda have about equal numbers of each in the blood. If one is higher than the other, however, it can be a sign of myeloma.