Neuroscientists have demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits.

Insulin is one of the most commonly used therapeutic agents used in diabetes. While the structure of this complex protein has been studied in detail there were parts of the receptor for insulin ...

Menting and colleagues' structures also provide insights into the receptor-activation mechanism. If the L1 domain from the insulin-bound structure is superimposed on L1 from the apo structure ...

Walter and Eliza Hall Institute scientists have determined the structure of a previously unseen part of the insulin receptor, making possible new treatments for diabetes. The insulin receptor is a ...

Australian scientists revealed the molecular structure of a hitherto unknown region of the insulin receptor. This could pave the way for new treatment for diabetes. The major part of the insulin ...

In the new study, Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain, the researchers show how insulin binds to site 2. Using a powerful technique known as cryo ...

Weiss and the international team figured out the insulin-receptor structure by a complicated combination of X-ray imaging and genetic engineering. "We used site-directed photo cross-linking made ...

Such a receptor molecule could be used in glucose-monitoring devices or insulin-dispensing devices ... roof and floor elements of the receptor structure, which allows an increased number of ...

Blakeley used cryo-electromagnetic microscopy to visualize the structure of the new insulin and how it interacts with its receptor. Normally, the human insulin receptor is activated by the same region ...

has demonstrated for the first time in living animals that insulin receptors in the brain can initiate signaling that regulates both the structure and function of neural circuits. The finding ...

Walter and Eliza Hall Institute scientists have determined the structure of a previously unseen part of the insulin receptor, making possible new treatments for diabetes. The insulin receptor is a ...