The cellular signal for insulin secretion is an influx of calcium ... in the cells' architecture is at the heart of the secretion defect. Using high resolution microscopy, the group found that ...

Mice engineered to have just one instead of two copies of the Nampt gene had a mildly impaired ability to metabolize glucose and had a defect in insulin secretion. The researchers showed that NMN ...

The persistent inability of cells to respond to this increased secretion triggers ... multifactorial nature of insulin resistance but assume that target tissue/cell defects or insulin receptor ...

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is ...

Defects in the metabolism of glucose in pancreatic beta cells may be the mechanism by which insulin secretion is impaired in type 2 diabetes. Thus, lessons learned from studies of MODY may improve ...

In spite of this remarkable insulin secretion, his blood glucose level ... biologic than immunologic activity or that the muscle defect in myotonic dystrophy binds most of the endogenous insulin ...

“These data demonstrate that in nonobese type 2 diabetes, early in the disease course insulin secretion defects predominate with impaired beta-cell sensitivity to glucose and less efficient ...

The research team hypothesizes that this secretion failure may result from decreased beta cell mass, a feature that has been associated with maternal low-protein diets in mice. Weanling rats fed with ...

in response to glucose—a process that is aptly called glucose-stimulated insulin secretion (GSIS). DA negatively regulates GSIS, leading to transient changes in the body's levels of insulins.

The cellular signal for insulin secretion is an influx of calcium ... in the cells' architecture is at the heart of the secretion defect. Using high resolution microscopy, the group found that ...