Mislocalized calcium channel causes insulin secretion defect in diabetes Date: May 19, 2017 Source: Uppsala Universitet Summary: Researchers have studied beta cells of type-2 diabetic donors, and ...

Mislocalized calcium channel causes insulin secretion defect in diabetes. Uppsala University. Journal Journal of Clinical Investigation DOI 10.1172/JCI88491 ...

Cosimo Giannini, MD, from the Yale University School of Medicine in New Haven, CT, and colleagues examined insulin secretion and sensitivity in 60 obese adolescents whose two-hour post-oral ...

The pathways that control insulin secretion and regulate pancreatic β-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of ...

Enzyme Defect Leads To Hyperinsulinism Date: May 25, 2006 ... The majority of cases of congenital hyperinsulinism appear to be due to defects in insulin secretion by pancreatic cells.

In a new study, researchers from the universities of Uppsala and Lund show why insulin secretion is not working properly in patients suffering from type-2 diabetes. The report is published in the ...

They concluded that the "insulin secretion defect in patients carrying the ADRA2A risk genotype can be corrected by alpha(2A) adrenergic receptor antagonism" and that this may provide a "new ...

More recently, it has been noted that carbohydrate metabolism in patients with myotonic dystrophy is abnormal. Reports of both an increased occurrence of diabetes mellitus 1,3,6 and unusually flat ...

Researchers reveal insulin resistance may be driven by insulin degradation during transit in the bloodstream, challenging the belief that cell defects are the primary cause.

Among women with gestational diabetes mellitus (GDM), impaired insulin sensitivity, but not insulin secretion defects, is associated with a greater risk of adverse outcomes compared with normal ...

More information: Nikhil R. Gandasi et al. Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes, Journal of Clinical Investigation (2017).DOI: 10.1172/JCI88491 ...