The team followed up with a long series of experiments to characterize the protein, TMEM24, and determined that is involved in the insulin secretion pathway. Beta cells normally secrete insulin ...

Researchers are reporting the identification of a new biochemical pathway to control insulin secretion from islet beta cells in the pancreas, establishing a potential target for insulin control.

Understanding how this pathway is regulated could lead to ... Instead of being shuttled through the ER for conversion to insulin and secretion, most parent molecules of insulin were degraded ...

Figure 5: Glucose intolerance, decreased insulin secretion and KIR6.2 levels in C57Bl/6 treated with CDK4 inhibitor. In summary, we have shown that the CDK4–pRB–E2F1 pathway mediates the ...

A crucial link between high levels of insulin and pathways that lead to obesity ... Insulin blocks the secretion of glucagon, opposes glucagon action on the liver, and instructs the body to ...

The researchers assert that the enzyme secreted by fat cells, called Nampt, is an important component of the insulin-secretion pathway. "We think this secretion process allows fat cells to ...

the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and impaired insulin secretion. Therefore, we propose here that the ...

The experiments resulted in an increased insulin secretion in the islets of Langerhans ... can regulate many proteins in a cell or signaling pathway. MicroRNA are involved in the development ...