The integrase enzyme binds to host cell DNA, prepares an area on the viral DNA for integration ... Drugs from the following classes are mostly used when resistance has developed to first-line or ...

INSTIs block integrase, an enzyme that HIV uses to put HIV DNA into human DNA inside the CD4 T cells. INSTIs belong ... are rare for use as first-line treatments. HIV can mutate and become ...

No writing assistance was utilized in the production of this manuscript. Dolutegravir is an HIV integrase strand transfer inhibitor (INSTI) that does not require pharmacokinetic boosting ...