The detailed sequence of events following ECM binding to the integrin is not known ... focal adhesions because it binds to paxillin. Upon activation, FAK combines with Src or Fyn — Src-family ...

To confirm in vitro observations, two in vivo assessments were carried out using hyaluronic acid hydrogels encapsulated with fibronectin fragments to activate the two integrin types — α3/α5β1 ...