The detailed sequence of events following ECM binding to the integrin is not known ... focal adhesions because it binds to paxillin. Upon activation, FAK combines with Src or Fyn — Src-family ...

leading to the inactivation of integrin β1 and the suppression of TGFβR/Smad signaling. This cascade of events results in the inhibition of EndMT. The activation of FGFR1 by KLX was confirmed ...

To confirm in vitro observations, two in vivo assessments were carried out using hyaluronic acid hydrogels encapsulated with fibronectin fragments to activate the two integrin types — α3/α5β1 ...