To confirm in vitro observations, two in vivo assessments were carried out using hyaluronic acid hydrogels encapsulated with fibronectin fragments to activate the two integrin types — α3/α5β1 ...
They discovered that patients with ulcerative colitis carry autoantibodies that target integrin alpha-v/beta-6, a protein that connects epithelial cells in the intestine to other types of tissue.
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