Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. Journal of Cell Biology , 2022; 221 (12) DOI: 10.1083/jcb.202201024 Cite This Page : ...

Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA.

For example, nuclear size and shape is also governed by emerin, which binds to lamins at the nuclear envelope (NE) and upon lamin loss is retained in the endoplasmic reticulum.

The double-stranded DNA molecules that make up the genetic material are wrapped around protein complexes to form compacted “chromatin”. The active portion of the genome is less densely packed, and ...

For instance, they found that rapid repair did not occur or was weakened in lamin C mutants, namely R435C, R471C, R527H, A529V, and K542N, compared to wild type (control) lamin C that did not have ...

In contrast, the expression of LAP1B could not improve nuclear envelope bleb formation unless either its Torsin-1A activation ability or the strong lamin-binding domain on its amino acid terminal ...

Approximately 33.6% of reads were mapped within 200 nm of nuclear proteins. DNA regions near the nuclear shell (lamin) tended to be inactive, whereas regions near nuclear speckles tended to be active.

Using immunofluorescence and live-cell imaging, Tokyo Tech researchers were recently able to determine the mechanism underlying the repairing mechanism of the nuclear envelope, which play a key ...