However, the rate of these changes declines in senescent cells and thus Lamin B1 is degraded more ... which are abnormal protein aggregates characteristic of SCA1. In turn, this lowered the ...

Shedding new light on protein aggregates and the diseases they cause Date: July 13, 2016 Source: Genetics Society of America Summary: Researchers have developed a system capable of quickly ...

Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease. A new study by the Nyström lab at Gothenburg ...

Super-resolution microscopy reveals lamin protein meshwork at the inner side of the nuclear membrane Sep 8, 2017 Microtubules anchored to proteins in the nuclear membrane position muscle cell nuclei ...

Protein aggregation is a continuous cellular process and may be a result of misfolding caused by various stressors. Chaperone complexes, in conjunction with interacting ubiquitin E3 ligases, channel ...

In Alzheimer's, Parkinson's, and type 2 diabetes, harmful protein aggregates and deposits, known as amyloid plaques, develop. There is also much evidence that these three diseases are ...

If the protein TDP-43 is defective inside a nerve cell it can form neurotoxic aggregates, which are the cause of the neurodegenerative disease amyotrophic lateral sclerosis (ALS).

Although the causal link between protein aggregates and neurodegeneration is clear, how misfolded proteins trigger cell death is not known. A team headed by Professor Jörg Tatzelt, head of the ...

New technology interfaces protein aggregate detection with high-throughput screening in live cells, opening new avenues to study prions, Huntington's, and other diseases - Researchers from the ...