Genetic linkage analysis can be used as a tool for estimating the genetic distance between two loci. In family data, a small recombination fraction between a hypothesized disease locus and a ...

To identify causative genes, we performed whole-exome sequencing in each family in parallel with linkage analysis. We anticipated that the combination of linkage analysis and exome sequencing ...

We used linkage analysis to establish genetic linkage between a gene causing familial amyotrophic lateral sclerosis and DNA markers from chromosome 21q22.1–22.2. 21 This linkage clearly ...

To search for cold sore susceptibility genes, the U researchers used linkage analysis, which traces genetic markers in families to identify regions on chromosomes that harbor disease genes.

Two major approaches have been used to define the genetic factors in SLE: linkage studies and association ... have been established through meta-analysis. Newly discovered associations with ...

Recently, a latest form of genetic research ... a rank-based analysis that assesses the strongest evidence for linkage within bins of a 30-centimorgan width on autosomes and the X chromosome.

Basic concepts in population genetics, including nucleotide diversity, random genetic drift, effective population size, coalescent theory, time to common ancestor, site frequency spectrum, linkage ...

The findings are published in Nature in an article titled, “Transcriptional linkage analysis with in vivo AAV-Perturb-seq.” “The ever-growing compendium of genetic variants associated with ...