What is the likelihood that all your lysosomes could burst at the same time? Would you spontaneously dissolve? – Annika, 12, ...

Researchers have revealed the structure and function of a previously unknown lysosome transporter. The groups of Christian Löw (CSSB, EMBL Hamburg), Markus Damme (Christian-Albrechts-University ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

Now, University of Michigan researchers have identified a new gene implicated in the disease, TMEM251, which is necessary for lysosomes to function correctly. Lysosomes are organelles within all ...

Lysosomes' function is driven by signals involving calcium ions (Ca2+). These ions are important messengers both within and between cells, and are involved in regulating nearly all the body's ...

Theories pegged progranulin functions as a growth factor or an antiinflammatory protein. More recent work put progranulin front and center in lysosome function, but did not explain what it did there.

The function of lysosomes is tightly regulated by complex cellular signals, including calcium ions moving into and out of lysosomes. Scientists have known how lysosomes release their calcium since ...

Because lysosome dysfunction is also a prominent ... STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders ...

Those that grow or decrease would point scientists to certain pathways or functions. Except for the little extra tag on each lysosome, these "LysoTag" mice are otherwise normal laboratory mice.

“What’s beautiful about this system is that all of the components of the PITT pathway were known to exist, but they weren’t known to interact in the sequence or for the function of lysosome repair,” ...