Muscarinic receptors constitute a family with five subtypes, M1–M5 (ref. 1). M1, M3 and M5 subtypes couple with the G q family of G proteins, and M2 and M4 subtypes with the G i /G o family of G ...

G protein-coupled receptors (GPCRs) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases. Upon binding to extracellular ...

Just Because a G-Protein ... M1 receptor. This technical achievement allowed Heptares to design a selective agonist against this receptor without cross-activation of the M2 or M3 receptors.

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

The G-protein coupled receptor Gpr3 helps γ-secretase pump out Aβ, and targeting the receptor may present a therapeutic strategy, according to a study published in Science Translational Medicine on ...

Over 50% of the drugs that are presently approved target human membrane proteins. G protein-coupled receptors (GPCRs) are the largest group of membrane proteins. The key work of GPCRs is to ...

G protein-coupled receptors (GPCRs) play essential roles in cell signal transduction and serve as important therapeutic targets for a large number of diseases. Upon binding to extracellular ...