Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...
Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates ... of target genes involved in cell cycle progression. The pRB/E2F signaling pathway is controlled by ...
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