Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...

"It challenges the assumption that more MYC is always better for a cancer cell—there's a real fitness cost to maintaining ... "We knew the tumor's surroundings could drive changes, but not that WNT ...

Mechanistically, transcriptome analysis revealed that IFN-γ reversed most iMEK-induced global transcriptomic changes, partly by regulating Wnt/β-catenin signaling and the transcription factor Myc.

Our laboratory studies oncogene and tumor suppressor induced cancer-specific cellular programs, which cause therapeutic vulnerabilities in breast cancer. Our current research specifically focuses on ...