Does MYC binding to chromatin serve transcription-independent functions, including the regulation of chromosomal integrity, gene expression, chromatin structure, cellular replication and genomic ...

The MYC gene is a regulatory and proto-oncogenic gene that is overexpressed in the majority of prostate cancers (PCa). Numerous studies have indicated that aberrant expression of microRNAs is ...

Known as ecDNA, these genetic rings float freely in the cell nucleus, enabling tumor cells to swiftly ramp up gene expression ... to big variations in MYC expression." To see how ecDNA drives ...

Research led by Children's Hospital of Fudan University in China has found that a gene called pancreatic progenitor cell ...

In their paper the researchers’ stated, “Collectively, our work establishes MYC ecDNAs as a key driver ... enabling tumor cells to swiftly ramp up gene expression, change their shape, and ...

Immunofluorescence images showing that cells with higher levels of the cancer-promoting MYC protein (red ... enabling tumour cells to swiftly ramp up gene expression, change their shape, and ...