More information: Emily M. King et al, Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific ...

They showed that lung vascular disease is preceded by inflammation. Later, they found that specific subtypes of macrophages ...

This dysfunction resulted in disruption of the macrophage’s ability to function properly, leading to persistent inflammation and lung scarring, key contributors to long COVID symptoms.

“We were expecting to see maybe neutrophils or T cells, but the amount of macrophages we saw in the samples was huge,” Marichal said. “They are not normally present in a healthy lung [in large numbers ...

such as the concentration of macrophages and other inflammatory immune cells. While they're exploring sarcoidosis first, efzofitimod is a potential treatment for many interstitial lung diseases ...