According to new research findings presented at the 2019 ACR/ARP Annual Meeting, adenosine deaminase 2 (ADA2) in the peripheral blood is a sensitive, specific biomarker for macrophage activation ...

This Case Study describes a 13-year-old girl with systemic juvenile idiopathic arthritis who developed features consistent with macrophage activation syndrome. The patient's disease remained ...

In view of the speculative importance of these differences, the study concludes, “Macrophages play a pivotal role in determining COVID-19 severity, but the consequences of macrophage activation ...

Peripheral-blood (PB) samples from 151 patients were collected on day 0 and day 4 of cycle 1. PB from a subgroup of 35 patients had intravenous (IV) instead of SC GM-CSF during cycle 4. Samples were ...

DC-9476 blocked MAS disease development by direct inhibition of macrophage activation, and this had broad activity causing a decrease in the production on (IL)-1β, IL-18 and other MAS-related ...

However, the mechanisms underlying cell entry and activation within the brain were poorly understood,” says Harms. “Through experiments in a Parkinson's disease rodent model and confirmed with human ...

BOSTON, September 17, 2024--DeepCure to Present In Vivo Efficacy and Safety Data of BRD4 (BD2) Inhibitor DC-9476 for Macrophage Activation Syndrome at EMBO Conference ...