The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the endosomal–lysosomal system.

M011, a highly phosphorylated recombinant β-glucosidase (GCase) enzyme with a high affinity for the cation independent mannose 6-phosphate receptor (CI-MPR), demonstrated superiority to ...

Using our technology platform, we enhance mannose 6-phosphate content on lysosomal enzymes for both enzyme replacement and gene therapies, leading to improved enzyme uptake across target tissues.” ...

Bertozzi’s seminal work in this space showcased how another receptor, the cation-independent mannose-6-phosphate receptor (CI-M6PR), could be used to hijack the endolysosomal recycling machinery.

Nexviazyme is designed to target the mannose-6-phosphate (M6P) receptor – a key pathway for cellular uptake of ERT in Pompe disease. In the Phase III COMET trial, comparing Nexviazyme to the older ERT ...

Mannose enters cells using the same receptors as glucose. Once within the cell, it accumulates as mannose-6-phosphate. As this metabolite builds up, it slows down glucose metabolism.

This study represents a critical step towards a greater understanding of how targeted protein degradation can be manipulated to improve degradation activity, for example by disrupting the production ...

This novel approach has the potential to use the receptor as a tool to deliver biomolecules/drugs into the cells in a mannose 6-phosphate dependent manner. Additionally letcin nanoparticles have also ...