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Via these mannose 6-phosphate (M6P) residues lysosomal enzymes can bind to mannose 6-phosphate receptors (M6PR), which mediate the further vesicular transport from the Golgi apparatus to the ...
The mannose 6-phosphate/IGF-2 receptor has been proposed to be a tumor suppressor gene on the basis of loss of heterozygosity and mutations in tumors from cancer patients. To test this hypothesis ...
Hence, mannose has high potential as cancer cell-specific ligand for the targeted delivery of (chemo)therapeutic nanocarriers. The ‘lock and key principle’ describes the binding of such functionalized ...
M011, a highly phosphorylated recombinant β-glucosidase (GCase) enzyme with a high affinity for the cation independent mannose 6-phosphate receptor (CI-MPR), demonstrated superiority to ...
Using our technology platform, we enhance mannose 6-phosphate content on lysosomal enzymes for both enzyme replacement and gene therapies, leading to improved enzyme uptake across target tissues.” ...
Nexviazyme is designed to target the mannose-6-phosphate (M6P) receptor – a key pathway for cellular uptake of ERT in Pompe disease. In the Phase III COMET trial, comparing Nexviazyme to the older ERT ...
Bertozzi’s seminal work in this space showcased how another receptor, the cation-independent mannose-6-phosphate receptor (CI-M6PR), could be used to hijack the endolysosomal recycling machinery.
This study represents a critical step towards a greater understanding of how targeted protein degradation can be manipulated to improve degradation activity, for example by disrupting the production ...