Analysis of large protein complexes by NMR spectroscopy. Methyl groups as probes. Critical to the success of any NMR study is the incorporation of NMR-active labels that can be used as probes 14.

Two-dimensional (2D) 1H-13C methyl correlated NMR is increasingly being recognized as a powerful tool to characterize the higher order structure (HOS) of monoclonal antibody (mAb) therapeutics. 2D ...