Pretreatment with sodium bisulfite is the basis of many methylation detection and analysis techniques. 1 Following bisulfite conversion, researchers determine the methylation status in loci of ...

PacBio has announced plans to enhance its methylation detection capabilities ... from native DNA without the need for chemical conversion, additional sample preparation, or parallel workflows.

have demanded more advanced tools. Enter DNA methylation- a subtle but incredibly powerful layer of genetic regulation that is now transforming the forensic landscape. DNA methylation is a ...

But amplification of DNA removes methylation marks. For a targeted capture approach to work, researchers must either capture first, then do bisulfite conversion and amplify, called ‘post-capture ...

Company licenses novel deep learning-based epigenetic models from CUHK enabling the detection of 5hmC, 5mC hemimethylation, and 6mA in standard sequencing runsMENLO PARK, Calif., April 28, 2025 (GLOBE ...

Methylation of cytosines in CpG dinucleotides ... This is required for the conversion of the PCR product to single-stranded DNA templates. A sequencing primer is then added, which anneals to ...

For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...

Additional data presented will underscore the potential of GRAIL's ctDNA-based targeted methylation assay for quantifying abnormal promoter methylation, which is a known hallmark of cancer and has ...