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Study reveals critical role of tRNA modifying enzyme in brain function
A study conducted by a research team from Kumamoto University has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the ...
Nature1y
The Role of Methylation in Gene Expression
DNA methylation is one of several epigenetic mechanisms ... Likewise, demethylated DNA does not attract deacetylating enzymes to the histones, allowing them to remain acetylated and more mobile ...
Biologists discover how plants evolved multiple ways to override genetic instructions
"This is the focus of our study. The question is—why do plants need extra methylation enzymes?" Looking forward, Zhong's ...
EMBO Press17d
DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cells
Concurrent analysis of whole-genome DNA methylation and single-cell RNA sequencing data from COVID-19 patients and controls reveals gene regulatory alterations in airway epithelial and immune cells.
Nature1y
Linking DNA methylation and histone modification: patterns and paradigms
Although DNA methylation and histone modification are carried out by different chemical reactions and require different sets of enzymes, there seems to be a biological relationship between the two ...
The Scientist2y
Brush Up: What Is Bisulfite Sequencing and How Do Researchers Use It to Study DNA Methylation?
With RRBS, scientists enrich for GC-rich parts of the genome by digesting the DNA with an enzyme that generates fragments with CpG dinucleotides at both ends, independent of methylation status. This ...