Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies with its lead development candidate, intranasal ...

Our previous research demonstrates that the CD40 signaling is critically involved in microglia-related immune responses in the brain. For example, it is well known that the activation of the ...

Additionally, the study explores mechanisms underlying microglial activation and its effects on neuronal health, focusing on the interplay between inflammatory pathways and mitochondrial dynamics.

Interestingly, this process seemed to operate independently of NFAT5, suggesting multiple activation pathways are involved in the microglial response to hyperosmotic stress. Additionally ...

The paper, published Wednesday in Science Translational Medicine, shows the potential of inhaled xenon to activate the brain’s immune cells, called microglia, to break down plaques that are a ha ...

Here authors demonstrate a role for nonapoptotic caspase-3 activation in neurons with elevated activity, in the promotion of C1q deposition and synaptic phagocytosis by microglia. Microglia and ...

Ncardia’s iPSC-derived microglia may aid ALS research and help to screen new therapies that target inflammation in ALS.

In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in ...

Specifically, the toll-like receptor 4 appears to be a site at which drugs of abuse activate microglia. Toll-like receptor 4 activation consequently produces an innate immune response in the brain ...

Researchers have unveiled transformative insights into the relationship between inflammation and depression, a finding that ...