The mitochondrial Complex I plays a central role in cellular respiration and energy metabolism. The ~1 Megadalton L-shaped protein complex is the largest protein assembly of the respiratory chain and ...

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. BMC Biology , 2016; 14 (1) DOI: 10.1186/s12915-016-0287-9 Cite This Page : ...

Structure of mammalian respiratory complex I Date: August 12, 2016 Source: MRC Mitochondrial Biology Unit Summary: New research outlines discoveries on the complex I (NADH:ubiquinone ...

Mitochondrial dysfunction often leads to cell death and disease. We can now draw correlations between the dysfunction of one of the most important mitochondrial enzymes, NADH:ubiquinone reductase ...

Cryo-EM structure of complex I from Yarrowia lipolytica at 2.1 Å resolution: Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is the largest and most intricate membrane protein complex of the ...

Mitochondria possess their own DNA (mtDNA), which plays important roles in cellular respiration and energy consumption.

The mitochondrial respiratory chain has the crucial function of ... HP, Eng, C. Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial ...

Led by CNIC scientists José Antonio Enríquez and Pablo Hernansanz, the research team used an array of mutants and diverse genetic models to demonstrate that mitochondrial complex I exchanges ...

Tokyo, Japan – Scientists from Tokyo Metropolitan University have shown that 5-aminolevulinic acid (5-ALA) helps bypass deficiencies in Complex I (CI), the first in a series of protein complexes ...