Mitochondrial outer membrane permeabilization is often required for activation of the caspase proteases that cause apoptotic cell death. As a consequence, the integrity of the mitochondrial outer ...

Rather than being like battery chargers, mitochondria are more like the motherboard of the cell.

The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into ...

The soluble Bax protein is responsible for the clearance of old or diseased cells, and when activated, it perforates the cell mitochondrial outer membrane to form pores that trigger programmed ...

Removing mitofusins from the outer mitochondrial membrane inhibits fusion and prevents abnormal mitochondria from reintegrating into the network, thereby facilitating mitophagy. 47 This so-called ...

image: MTCH2 acts as a doorway for proteins into the outer mitochondrial membrane. view more Credit: Maria Guna. Mitochondria — the organelles responsible for energy production in human cells ...

Mitochondria are specialized cellular structures that power various functions. ... the outer membrane is more porous and is less selective about which materials it lets in.

Formation of pores in mitochondrial membrane elucidated. University of Freiburg. Journal Nature Structural & Molecular Biology DOI 10.1038/s41594-022-00897-2 ...

Panel D shows mitochondrial ultrastructure and compartmentalization, highlighting the mitochondrial outer membrane (MOM), mitochondrial inner membrane (MIM), and intermembrane space (IMS).

Researchers from the Max Delbruck Center for Molecular Medicine have identified how the inner membranes of mitochondria “get their groove” and assume the complex shapes they need to carry out crucial ...

This can be offset by Bcl-2, which is embedded within the mitochondrial membrane, where it acts to prevent untimely cell death by capturing and sequestering Bax proteins.