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Mitochondrial outer membrane permeabilization is often required for activation of the caspase proteases that cause apoptotic cell death. As a consequence, the integrity of the mitochondrial outer ...
The general preprotein translocase of the outer mitochondrial membrane (TOM complex) transports virtually all mitochondrial precursor proteins, but cannot assemble outer-membrane precursors into ...
The soluble Bax protein is responsible for the clearance of old or diseased cells, and when activated, it perforates the cell mitochondrial outer membrane to form pores that trigger programmed ...
Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...
Removing mitofusins from the outer mitochondrial membrane inhibits fusion and prevents abnormal mitochondria from reintegrating into the network, thereby facilitating mitophagy. 47 This so-called ...
image: MTCH2 acts as a doorway for proteins into the outer mitochondrial membrane. view more Credit: Maria Guna. Mitochondria — the organelles responsible for energy production in human cells ...
Formation of pores in mitochondrial membrane elucidated. University of Freiburg. Journal Nature Structural & Molecular Biology DOI 10.1038/s41594-022-00897-2 ...
Mitochondria are often called the powerhouses of the cell. ... Outer membrane: Small molecules can pass freely through this. This outer portion includes proteins called porins, ...
MTCH2's ability to shuttle proteins from the cytoplasm into the mitochondrial membrane is likely due to its specialized shape. The researchers ran the protein's sequence through Alpha Fold, an ...
In contrast, the Sam37 subunit has a protrusion that extends into the mitochondrial outer membrane, around which the strands of the beta-barrel proteins are arranged in a circular fashion.