Essentially, cereblon and its target proteins can change shape to form a complex with the cereblon, the target, and the ...

Monte Rosa’s AI/ML-powered insights dramatically increase targetable protein space for molecular glue degraders, unlocking ...

Protein structures could guide the design of molecular glue degraders. Many conventional small-molecule drugs work by inhibiting proteins, affecting their function.

"Molecular glue degraders have the potential to target many proteins now considered undruggable, but finding them is challenging," said Science Executive Editor Valda Vinson."The judges were impressed ...

Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis. Scientists think that with the help of “matchmaker” molecules called molecular glue ...

Scientists at St. Jude Children’s Research Hospital collaborated to identify and improve a chemical compound that acts as a molecular “super-glue” with broad activity across cancers.

The researchers showed that the molecule UM171 works as a glue that can trigger the breakdown of the CoREST complex, an organizing system that controls access to genes.

The team then added a molecular “glue” to the ink that, when laser activated, formed stable bonds between the nanocrystals, resulting in robust 3D structures.

Cells contain molecular machinery that targets and disposes of unwanted proteins and keeps the cell functioning normally. Scientists would like to hijack this process to control proteins involved in ...