As expected, the glutamine was converted into glutamate, a molecule that was then made into GABA by the enzyme glutamic acid decarboxylase (two versions of this enzyme are dubbed GAD65 and GAD67).

Breakthrough study reveals new insights into GABA, the brain's key signaling molecule The review is expected to offer a guideline for understanding the human brain Date: September 5, 2023 Source ...

A new study in a mutant fruit fly called sleepless (sss) confirmed that the enzyme GABA transaminase, which is the target of some epilepsy drugs, contributes to sleep loss. The findings, published ...

Adding those molecules -- a GABA-like molecule and another, called a positive allosteric modulator or PAM, that fine-tunes GABAB function -- stabilized GABAB receptor in its active state.

GABA production in the liver is governed by an enzyme called GABA transaminase. The researchers blocked production of this enzyme in type 2 diabetes animal models to test whether the mechanism ...

The team was able to observe that the GAT structure was facing the cytosol – the inside of the cell – and was bound to a GABA molecule, sodium and chloride ions. This binding is one of many ...

Metamorphosis, or a dramatic change in physical appearance, is a normal part of the life cycle of many animals, carried out to take advantage of different ecological niches. Yet the process of ...

Sage Therapeutics is now in a license agreement with Washington University in St. Louis to develop and commercialize novel small molecule GABA A receptor allosteric modulators for treating ...

In a groundbreaking review paper published in Nature Reviews Neuroscience, scientists have shed new light on the role of GABA, a key signaling molecule in the brain. Researchers from the Center ...

For researchers looking to understand and someday treat certain neuropsychological ailments, one place to start is a molecule known as GABA, which binds to receptor molecules in neurons and helps ...