Since monoclonal antibodies are highly specific for a single ... Köhler and Milstein fused the antibody-producing plasma cells with immortal myeloma cancer cells. This hybrid cell line had the ...

Monoclonal gammopathy of undetermined significance (MGUS ... Like multiple myeloma, MGUS starts in a type of white blood cell called plasma cells. These cells make m-protein. This abnormal protein can ...

Monoclonal B-cell lymphocytosis is when your body produces an elevated number of identical B cells. In some cases, it can develop into chronic lymphocytic leukemia. Monoclonal B-cell lymphocytosis ...

View Full Profile. Learn about our Editorial Policies. Scientists create monoclonal antibodies by cloning a single antibody-producing cell line. In contrast to polyclonal antibodies, monoclonals are ...

The first phase of abnormal plasma cells building up in the bone marrow without causing symptoms or complications is a benign (noncancerous) condition called monoclonal gammopathy of undetermined ...

Cell lines commonly used for monoclonal antibody expression include Chinese hamster ovary (CHO) and human embryonic kidney 293 (HEK293) cells. But even if researchers have worked with these wild ...

Abnormal plasma cells begin to grow very quickly ... active myeloma or another condition that can be a precursor to it: ...

Existing monoclonal antibody development technologies ... sorting platform automatically screens tens of thousands of plasma cells procured from immunized animals, reducing the monitoring process ...

Multiple myeloma can arise when plasma cells transform into malignant plasma cells which leads to the uncontrolled growth of these abnormal plasma cells.