This waste travels through the collecting duct of the nephron, where excess water is absorbed back into the bloodstream. The remaining waste travels on to the bladder, where it is eventually excreted.

Nephron progenitors differentiate into the renal tubules that reabsorb salt and water in the urine, and ureteric buds differentiate into the collecting ducts that collect urine and reabsorb water.

We have highlighted the utility of this model for investigating collecting duct and distal tubule injury and for identifying the underlying mechanisms of the distal nephron’s contribution to the ...

In the embryonic kidney, three types of precursor cells interact with each other to form a three-dimensional structure. Previous studies successfully induced nephron structures via nephron ...

image: [LEFT] The higher-order structure of the kidney reconstructed from mouse ES cells (low magnification, green: collecting tube, red: nephron progenitor cells). [RIGHT] The nephron connected ...

Diuretics are particularly effective in minimizing hyperkalemia. Diuretics enhance the excretion of potassium in the kidney by increasing the delivery of sodium to the collecting duct.

"Our engineered mouse kidney established a connection between nephron and collecting duct--an essential milestone towards building a functional organ in the future," said Li.

Nephron progenitors differentiate into the renal tubules that reabsorb salt and water in the urine, and ureteric buds differentiate into the collecting ducts that collect urine and reabsorb water.

The human kidney is a masterclass in biological engineering. Responsible for filtering approximately 50 gallons of blood ...

However, a persistent limitation has been that these organoids lack a collecting duct system, which is required to carry fluid out of the nephron.

Nephron progenitors differentiate into the renal tubules that reabsorb salt and water in the urine, and ureteric buds differentiate into the collecting ducts that collect urine and reabsorb water.