Editor’s note: This article was last updated on June 27, 2021. It has been reviewed by Cars.com Senior News Editor Jennifer Harrington and is still accurate. An engine misfire is when one or ...

Question:I've already done a lot of work to a 2000 3.3-liter Nissan Frontier Crew Cab. It runs bad and has two codes, P0300 and P0400. ... P0300 is caused by a random cylinder misfire.