Most of these variants map to noncoding genomic regions ... Parking a giant CRISPR repressor on DNA is helpful for discovering causal variants, but it is not realistic in a biological sense. STING-seq ...

What about the rest of the cases of CHD? Noncoding DNA elements have long been thought to play a role in CHD, but few variants have been pinned down as causative. New work from the lab of ...

The researchers studied resistance variants found in the non-coding genome, which makes up 98% of DNA and does not contain genes. Previous attempts to identify resistance mechanisms to ...

Swiss start-up Haya Therapeutics has formed a partnership with Eli Lilly – worth up to $1 billion – to look for new therapies for obesity in non-coding DNA. The biotech focuses on trawling the ...

The involvement of noncoding mRNAs in many regulatory processes ... that an "RNA world" may have preceded the evolution of DNA and proteins (Gilbert, 1986). Small interfering RNAs (siRNAs ...

First, both coding and noncoding regions of DNA are transcribed into mRNA. Some regions are removed (introns) during initial mRNA processing. The remaining exons are then spliced together ...

A comparison of blood cells and tumor cells from these individuals revealed more mitochondrial segments in cancer cells, possibly because they experience more DNA damage. The mtDNA fragments tend to ...

It’s time to shine a light on the next wave of drug discovery.

Using single-cell RNA sequencing, we mapped thousands of expression quantitative trait loci in yeast, including a variant in GPA1 that influences gene expression, cell-cycle occupancy, and mating ...