PCR reactions are carried out at low annealing temperatures to reduce specificity of the primers in binding to the template clone DNA. In the final step an amino group is linked to the 5' end of ...

Antisense technology employs short, chemically synthesized oligonucleotides (antisense ... If binding affinity is sufficiently high, annealing of the antisense compound can block interaction ...

A new platform for making oligonucleotides offers chemists a way to plug in five types of nucleoside connections, so they can tailor properties of oligonucleotide therapeutics. These short DNA or ...

Eli Lilly is paying $13 million upfront, with $1 billion in biobucks up for grabs, for the opportunity to develop AI-designed oligonucleotide therapies from Creyon Bio. Oligonucleotides work as ...

Scientists have developed a new approach to produce life-saving oligonucleotide therapeutics on a large scale, in high purity, and with minimal environmental impacts. Scientists have developed a ...

A biochemical breakthrough using simple carbon atoms, by Ken Yamada, Ph.D., and Anastasia Khvorova, Ph.D., has dramatically improved the stability and efficacy of a potential oligonucleotide ...

Eli Lilly is looking to create new drugs for immunology and other diseases by combining antibodies and oligonucleotides—or short DNA or RNA molecules. To that end, it is handing over $20 million ...