How does a proto-oncogene become converted to an oncogene? (Figure 4) Occasionally, mutations will permanently activate proteins that normally interchange between active or inactive states.

p53 refers to the protein product of the TP53 gene. The traditional view of cancer development, driven by oncogene activation and tumor suppressor loss, has expanded to include genes involved in ...

Oncogene permanent activation in a single targeted cell of zebrafish together with a reprogramming factor transient activation is sufficient to induce the malignant transformation of the cell and ...