The researchers screened 238 known oncogenic mutations in 17 different proto-oncogenes. Out of the 17 genes, 14 were mutated in at least one sample, and 34% of the 238 oncogenic mutations were ...

For example, Ras proteins function ... use the transformation assay to identify oncogenes and tumor suppressors? These days, manipulating gene expression in cultured cells is easily done in ...

or the activation of an oncogene can lead to genome instability. Loss-of-function variants in genes encoding tumor suppressor proteins, such as those that mediate DNA repair and cell-cycle ...

Lung cancer (LC) is a major global health issue, with high mortality rates and limited therapeutic options. It is primarily categorized into non-small cell lung cancer (NSCLC) and small cell lung ...