Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

But, other scientists say, while in vitro and in vivo examples “abound,” documentation of the existence of oncogene addiction and its mechanistic underpinnings is just beginning to emerge.

Oncogenes: Protooncogenes are genes that are normally present in the body that code for the growth of cells, ... For example, most p53 gene mutations are somatic, or develop during adulthood.

These important genes are called proto-oncogenes. A change in the DNA sequence of the proto-oncogene gives rise to an oncogene, ... One example of a well known proto-oncogene is the HER2 gene.

Scientists studying the genetic switches that turn cancer on and off are producing some of the most widely cited papers in medical research today. In a January report, the Philadelphia-based Institute ...

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene—a gene that can cause cancer—that may ...

In lung adenocarcinoma, as in other types of cancer, gene amplification and the consequent overexpression of the amplified oncogene play an important role in the development of tumors, because ...

Science Express publication suggests that personalized medicine will need to include a focus on pathways that link uncommonly mutated genes. A consortium of scientists studied the vast majority of ...

LAWRENCE — Many people are familiar with oncogenes — genes long known to be involved in cancers in humans, such as the gene “Src.” ... “For example, in a human context, ...

Scientists have developed a novel method to identify genes that, when overexpressed, make normal cells behave like cancer cells. Using this method, scientists have identified a new oncogene, which ...

A new method, which uses the CRISPR/Cas9 system to generate liver cancer mouse models by rapidly adding (knocking in) cancer genes to DNA, is being reported in the open access journal Genome Medicine.