Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

This review summarizes current experimental and clinical evidence for the concept of oncogene addiction and describes molecular mechanisms that may explain this phenomenon. In addition ...

How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

Answers to several additional discrete questions regarding the mechanism of MYC action remain ... itself as such a universal and aggressive oncogene, a vital next step is to functionally ...

Further experiments revealed that TP63, an oncogene, acts as a "master switch" for ALDH3A1. It directly activates the ALDH3A1 ...

Microscopic command centers in our bodies called primary cilia—once thought irrelevant—could be hidden switches powering ...