Cancer has become one of the leading causes of death in the Western society. As current cancer therapies, like radiotherapy and chemotherapy, have often only a limited effect, a strong need exists ...

In this study, we evaluated the roles of c-Jun NH2-terminal kinase (JNK) in oncolytic vaccinia virus replication and vaccinia virus-mediated host cell killing. We found that JNK knockout mouse ...

Because of their excellent selectivity for infecting and lysing tumor cells, oncolytic ... the viral genome must be reformed and rebuilt to manage the pathogenic replication cycles that are ...

Oncolytic virus (OV)-based immunotherapy has emerged ... including improving viral infection and replication within tumor cells, modulating the suppressive TME, and addressing therapeutic resistance.

"Oncolytic viruses are attractive therapeutic ... "TNBC cells support efficient viral replication, with over 1 million copy numbers observed, which is more than a 1000-fold increase," she said.

Replication-selective oncolytic viruses are a rapidly expanding therapeutic platform for cancer. Professor Wang Shengdian and his group from the Key Laboratory of Infection and Immunity, Institute of ...

Investigators from Brigham and Women’s Hospital reported the results of a Phase I clinical trial evaluating a novel engineered oncolytic herpes virus (oHSV) in patients with high-grade recurrent ...

Oncolytic virus (OV)-based immunotherapy has emerged ... including improving viral infection and replication within tumor cells, modulating the suppressive TME, and addressing therapeutic resistance.

Injected into a solid tumor, replication of the virus kills cancer cells. This oncolytic virus is also intended to prompt an additional immune response against the cancer. Get your IV treatment ...

Oncorus has raised $79.5 million to advance oncolytic viruses. The series B round equips Oncorus to move its lead prospect into the clinic and nominate an intravenously administered viral ...