ABCB1 in the ABC transporter family also termed as P-glycoprotein ... researchers have tried to search for safe and specific inhibitors of this pump. Naturally occurring flavonoids as benzopyrone ...

In additional studies with P-glycoprotein third-generation inhibitors, the researchers found that these inhibitors also stabilize a symmetric state, but one that is different from the empty state.

Medication suggestions “Since P-glycoprotein inhibitors are quite common (eg, antibiotics, antidepressants and over 250 other drugs), it may be impossible to avoid these interactions,” Brown ...

The P value for the interaction was 0.016 ... We conducted a trial comparing two inhibitors of platelet glycoprotein IIb/IIIa, a group of agents that has been extensively investigated in the ...

P-glycoprotein (P-gp) knockout and wild-type mice. GF120918 is a potent inhibitor of BCRP and P-gp. The aim was to increase the bioavailability of topotecan by GF120918. PATIENTS AND METHODS: In ...

1.7%, P=0.28). Nonetheless, patients in whom PCI was performed and who were assigned to receive bivalirudin rather than heparin plus a glycoprotein IIb/IIIa inhibitor had lower 30-day rates of ...

The researchers conducted a series of studies designed to show the effects of single-dose colchicine given with known inhibitors of CYP3A4 or P-glycoprotein. The 168 study participants were ...

Taken together, these results suggest that patients should be prescribed alternative antibiotics if they are taking P-glycoprotein inhibitors such as statins, or if they have a particular genotype.

Some fish caught in the Gulf of Mexico off the coast of Louisiana were found to have levels of the pollutant to could lead to high levels of p-glycoprotein inhibitors. That finding could prevent ...