Mchaourab describes P-glycoprotein as a two-part molecular machine: an engine that burns ATP and a transmembrane domain that provides a passageway for the substrate (a molecule moved by the ...

P-glycoprotein (ABCB1 ... role in the disposition of numerous structurally diverse drugs that are its substrates (Benet et al, 1999). For example, owing to its active efflux, P-gp limits the ...

Similarly, several supportive care agents (such as granisetron, fentanyl, and oxycodone) are CYP3A4 or P-glycoprotein substrates, and patients taking opioids to manage pain relief could also ...

Well-known P-gp substrates, verapamil and talinolol, were perfused nasally or infused intravenously when plasma concentrations following intravenous infusion and nasal perfusion showed similar ...

To set the record straight, we draw your attention to the paper where it was first reported in 1997 that specific substrates and modulators could be used as a strategy to prevent protein misfolding in ...

Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC). This is an ASCO ...