More information: Reza Dastvan et al. Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors, Science (2019). DOI: 10.1126/science.aav9406.

Similar to the effects seen with the CYP450 systems, P-gp induction results in a decrease in systemic exposure of P-gp substrates, while inhibition will increase systemic exposure.

Role of P-Glycoprotein and Organic Anion Transporting Polypeptides in Drug Absorption and Distribution: Focus on H1-Receptor Antagonists . ... P-gp substrates that enter from the plasma ...

P-glycoprotein (Pgp), an ATP-dependent plasma membrane efflux pump, ... Seelig A A general pattern for substrate recognition by P-glycoprotein Eur J Biochem 1998 251 252–61.

Apixaban is a substrate of P-glycoprotein and P-glycoprotein inhibition increases drug exposure. Bleeding risk does not appear to increase when apixaban is given concomitantly with cardiac P ...

These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations." ### Contact: ...

Drug-drug interaction (DDI) of darolutamide with cytochrome P450 (CYP) and P-glycoprotein (P-gp) substrates: Results from clinical and in vitro studies. Authors: Christian Zurth, ... P-gp substrate) + ...

August 11, 2011 — In an unexpected finding, a preliminary study has revealed that the combination of lenalidomide (Revlimid) plus temsirolimus (Torisel) interacts with P-glycoprotein (P-gp ...

An article published in the journal Drug, Metabolism and Pharmacokinetics describes how researchers have evaluated the potential utility of the nasal route to enhance CNS drug delivery of drugs ...