The discovery of the Bcl-2 protein family, as well as p53 and its involvement in regulating apoptosis, and the CD95 (also known as FAS or APO1) pathway, led to an understanding of the molecular ...

Under normal, unstressed conditions, a key negative regulator of p53 is MDM2, which binds to the ... SOCS2 = suppressor of cytokine signalling 2; SOD2 = superoxide dismutase; [Mn] = mitochondrial ...

ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein, has improved AML treatment ... Moreover, this combination is active against P53-negative and FLT3-ITD-positive cell lines.