and p53 mutant tumors display rampant genomic instability (1). Wild-type p53 is often engaged in response to cellular damage, where it acts to regulate genes that promote cell-cycle arrest, apoptosis, ...

Malfunction of the p53 pathway is an almost universal hallmark of human tumours. [1,2] Somatic mutation of TP53 that results in the absence or dysfunction of p53 is one of the most common ...

Wild-type Ad5 generates cytopathic effect in cells expressing wild-type p53 but not in cells expressing mutant p53. These data indicate that p53 has a determining role in allowing adenovirus to ...

P53 Overexpression and mutation seen in children >3 years and young adults; possible independent prognostic factor Less common in elderly patients EGFR/EGFRvIII Less common in pediatric patients ...

One helper in this process is the p53 protein. However, when it mutates, it can no longer fulfil its task. Until now, researchers have assumed that the process is the same with all mutation types.

Kymera Therapeutics Inc. has published the characterization of KT-253, a novel compound designed to degrade the murine double minute 2 (MDM2) protein, offering a promising approach for cancers ...