Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...
Once researchers redefined p53 as a tumor suppressor gene and generated nonmutated clones, they began piecing together the puzzle of its role in the cell. One group showed that p53 controlled the ...
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When the number of chromosomes goes off track 🧬The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...
The University of Melbourne and affiliated organizations presented the development of a new reporter mouse model designed to study the role of MDM2 and its transcriptional regulation in p53-mediated ...
PNC-27 is a synthetic peptide composed of 32 amino acids. It is engineered to contain the MDM-2 binding domain of the tumor ...
The stem cell signal Msi2 plays a dual role in lung cancer, acting as a signal that is not only essential for initiation, but also for propagation of the tumor.
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