Under normal, unstressed conditions, a key negative regulator of p53 is MDM2, which binds to the transactivation domain of p53 and ubiquitylates the protein, targeting it for degradation.

The levels of p53 and Mdm2 are balanced through autoregulatory feedback loops — the RING-finger protein Mdm2 binds to p53 at its transactivation domain and thereby inhibits its transactivation ...

My colleagues and I are studying two other closely related proteins that regulate p53 by marking it for destruction when it's no longer needed. These proteins, called MDM2 and MDMX, become ...

Western blot assays were performed to identify the presence of p53, phospho-p53, and murine double minute 2 (MDM2) isoforms in plasma samples. Densitometric analysis was used to determine the ...

Navtemadlin is an MDM2 inhibitor that can help to kill cancer cells by boosting the activity of p53, a protein that controls cell growth and induces cell death in response to DNA damage.

The University of Melbourne and affiliated organizations presented the development of a new reporter mouse model designed to study the role of MDM2 and its transcriptional regulation in p53-mediated ...

Some potential cancer therapies may do more harm than good: A class of compounds intended to boost tumor suppressor p53 activity may actually promote mutant versions ...

Once everybody got on the same page, the community settled on a common name: p53. “The field looked at this and didn’t know what to make of it,” Levine said. “Because it wasn’t isolated like an ...

It also develops APG-2575, an oral administered Bcl-2 selective inhibitor for hematologic malignancies and solid tumors; APG-115, an oral small molecule inhibitor of the MDM2-p53 protein-protein ...